Article

TMEM2-mediated hyaluronan turnover maintains articular cartilage homeostasis during osteoarthritis progression

2025-12-12

Abstract excerpt

Osteoarthritis (OA) is a degenerative joint disease characterized by progressive disruption of the cartilage extracellular matrix (ECM), yet the molecular mechanisms governing ECM turnover during disease initiation remain incompletely defined. Hyaluronan (HA) is a major structural component of articular cartilage, and its regulated turnover is essential for maintaining tissue integrity. Transmembrane protein 2 (TM...

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Literature Corpus work: 84ee793e-0df7-57de-bf54-613bc56a26aa
DOI: 10.64898/2025.12.09.693317

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