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Article

Mice harboring a Hajdu Cheney Syndrome mutation are sensitized to osteoarthritis.

Bone - 1 Sept 2018

Zanotti S, Yu J, Bridgewater D, Wolf J M, Canalis E

Abstract excerpt

Osteoarthritis is a joint disease characterized by cartilage degradation, altered gene expression and inflammation. NOTCH1 and NOTCH2 receptors and the JAGGED1 ligand regulate chondrocyte biology; however, the contribution of Notch signaling to osteoarthritis is controversial. Hajdu Cheney Syndrome (HCS) is a rare genetic disorder affecting the skeleton and associated with NOTCH2 mutations that lead to NOTCH2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29940267
DOI: 10.1016/j.bone.2018.06.020
PMCID: PMC6083868

Genes

NOTCH2
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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