Article
Genomic profiles of colorectal cancers differ based on patient smoking status.
Cancer genetics and cytogenetics - 15 Jul 2006
Swede Helen, Bartos Jeremy D, Chen Neng, Shaukat Aasma, Dutt Smitha S, McQuaid Devin A, Natarajan Nachimuthu, Rodriguez-Bigas Miguel A, Nowak Norma J, Wiseman Sam M, Alrawi Sadir, Brenner Bruce M, Petrelli Nicholas J, Cummings K Michael, Stoler Daniel L, Anderson Garth R
Abstract excerpt
Human sporadic colorectal cancer is the result of a lengthy somatic evolutionary process facilitated by various forms of genomic instability. Such instability arises endogenously from mutations in genes whose role is to preserve genomic integrity, and exogenously from environmental agents that generate genomic damage. We have found that cigarette smoking shifts the genomic profiles and genomic instability...
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