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Article

Promoter Hypermethylation of Hallmark Cancer Genes in Atypical Adenomatous Hyperplasia of the Lung

1 May 2008

Abstract excerpt

PURPOSE: According to current models of tumorigenesis, the progression of phenotypic changes culminating in overtly malignant carcinoma is driven by genetic and epigenetic alterations. The recognition of an early form of glandular neoplasia termed atypical adenomatous hyperplasia (AAH), a precursor lesion from which lung adenocarcinomas arise, provides an opportunity for characterizing early epigenetic...

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Share to Epigenetics and DNA Methylation
Share to Lung Cancer Diagnosis and Treatment
Share to Lung Cancer Treatments and Mutations

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Identifiers

PMID: 18451218
DOI: 10.1158/1078-0432.ccr-07-2033

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