Article
Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association.
Diabetes care - 1 Oct 2015
Insel Richard A, Dunne Jessica L, Atkinson Mark A, Chiang Jane L, Dabelea Dana, Gottlieb Peter A, Greenbaum Carla J, Herold Kevan C, Krischer Jeffrey P, Lernmark Åke, Ratner Robert E, Rewers Marian J, Schatz Desmond A, Skyler Jay S, Sosenko Jay M, Ziegler Anette-G
Abstract excerpt
Insights from prospective, longitudinal studies of individuals at risk for developing type 1 diabetes have demonstrated that the disease is a continuum that progresses sequentially at variable but predictable rates through distinct identifiable stages prior to the onset of symptoms. Stage 1 is defined as the presence of β-cell autoimmunity as evidenced by the presence of two or more islet autoantibodies with...
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