Article
Derivation of ultrasound and electrocardiogram cardiac reference ranges for Mus musculus using the collaborative cross and identification of new cardiac models.
BMC cardiovascular disorders - 26 Sept 2025
Popp Julia L, Patel Krishna, Cuomo Danila, Lynch Rachel M, Leung Steve W, Berridge Brian R, Rusyn Ivan, Chiu Weihsueh A, Threadgill David W
Abstract excerpt
BACKGROUND: Contemporary approaches for developing interventions and assessing pre-clinical cardiovascular risk frequently utilize animal and in vitro models. However, these models currently lack normal species-specific reference ranges similar to what exists for humans. The genetically diverse Collaborative Cross (CC) population that models human genetic heterogenetiety was characterized to develop...
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