Mouse cardiac surgery: comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies

Abstract excerpt

Mouse models mimicking human diseases are important tools in trying to understand the underlying mechanisms of many disease states. Several surgical models have been described that mimic human myocardial infarction (MI) and pressure-overload-induced cardiac hypertrophy. However, there are very few detailed descriptions for performing these surgical techniques in mice. Consequently, the number of laboratories that...

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