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Article

Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models.

JCI insight - 22 Mar 2018

Vakrou Styliani, Fukunaga Ryuya, Foster D Brian, Sorensen Lars, Liu Yamin, Guan Yufan, Woldemichael Kirubel, Pineda-Reyes Roberto, Liu Ting, Tardiff Jill C, Leinwand Leslie A, Tocchetti Carlo G, Abraham Theodore P, O'Rourke Brian, Aon Miguel A, Abraham M Roselle

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) stems from mutations in sarcomeric proteins that elicit distinct biophysical sequelae, which in turn may yield radically different intracellular signaling and molecular pathologic profiles. These signaling events remain largely unaddressed by clinical trials that have selected patients based on clinical HCM diagnosis, irrespective of genotype. In this study, we determined how two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29563334
DOI: 10.1172/jci.insight.94493
PMCID: PMC5926940

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