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Unlocking HDR-mediated nucleotide editing by identifying high-efficiency target sites using machine learning

26 Feb 2019

Abstract excerpt

Editing individual nucleotides is a crucial component for validating genomic disease association. It is currently hampered by CRISPR-Cas-mediated "base editing" being limited to certain nucleotide changes, and only achievable within a small window around CRISPR-Cas target sites. The more versatile alternative, HDR (homology directed repair), has a 3-fold lower efficiency with known optimization factors being...

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PMID: 30808944
DOI: 10.1038/s41598-019-39142-0

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