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Article

Dominant-negative p53 mutant R248Q increases the motile and invasive activities of oral squamous cell carcinoma cells

1 Feb 2019

Abstract excerpt

The tumor suppressor gene TP53 (gene) codes for a transcription factor which transactivates its target genes responsible for cell cycle arrest, DNA repair, apoptosis, and senescence. TP53 is well known to be the most frequent target of genetic mutations in nearly half of human cancers including oral squamous cell carcinoma (OSCC). Many p53 mutants including R248Q and R248W not only lose its tumor-suppressor...

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PMID: 30787262
DOI: 10.2220/biomedres.40.37

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