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Article

Mutant p53 in head and neck squamous cell carcinoma: Molecular mechanism of gain‑of‑function and targeting therapy (Review).

Oncology reports - 1 Sept 2023

Li Minmin, Sun Dongyuan, Song Ning, Chen Xi, Zhang Xinyue, Zheng Wentian, Yu Yang, Han Chengbing

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is one of the most widespread malignancies worldwide. p53, as a transcription factor, can play its role in tumor suppression by activating the expression of numerous target genes. However, p53 is one of the most commonly mutated genes, which frequently harbors missense mutations. These missense mutations are nucleotide substitutions that result in the substitution of...

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Source

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Identifiers

PMID: 37449494
DOI: 10.3892/or.2023.8599
PMCID: PMC10394732

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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