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Article

Mutant p53 R248Q but not R248W enhances in vitro invasiveness of human lung cancer NCI-H1299 cells.

Biomedical research (Tokyo, Japan) - 1 Dec 2010

Yoshikawa Kazuhito, Hamada Jun-ichi, Tada Mitsuhiro, Kameyama Takeshi, Nakagawa Koji, Suzuki Yukiko, Ikawa Mayumi, Hassan Nur Mohammad Monsur, Kitagawa Yoshimasa, Moriuchi Tetsuya

Abstract excerpt

More than half of all human cancers are associated with mutations of the TP53 gene. In regard to the functional interaction with the remaining wild-type (WT) p53 allele, p53 mutations are classified into two types, recessive and dominant-negative (DN) mutations. The latter mutant protein has a DN...

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Source

Identifiers

PMID: 21187651
DOI: 10.2220/biomedres.31.401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21187651-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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