Mutant p53 in Cancer Progression and Targeted Therapies

Abstract excerpt

TP53 is the most frequently mutated gene in human cancers with a mutational frequency over 50% of all human cancers. Most of these p53 gene mutations are missense mutations, leading to the expression of the p53 mutant proteins. Mutant p53 proteins not only lose wild-type p53-dependent tumor suppressive functions, but also frequently acquire oncogenic gain of functions (GOF) that promote tumorigenesis. Intensive...