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Mutant p53 gain of function can be at the root of dedifferentiation of human osteosarcoma MG63 cells into 3AB-OS cancer stem cells.

Bone - 1 Mar 2014

Di Fiore Riccardo, Marcatti Michela, Drago-Ferrante Rosa, D'Anneo Antonella, Giuliano Michela, Carlisi Daniela, De Blasio Anna, Querques Francesca, Pastore Lucio, Tesoriere Giovanni, Vento Renza

Abstract excerpt

Osteosarcoma is a highly metastatic tumor affecting adolescents, for which there is no second-line chemotherapy. As suggested for most tumors, its capability to overgrow is probably driven by cancer stem cells (CSCs), and finding new targets to kill CSCs may be critical for improving patient survival. TP53 is the most frequently mutated tumor suppressor gene in cancers and mutant p53 protein (mutp53) can acquire...

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PMID: 24373920
DOI: 10.1016/j.bone.2013.12.021

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