Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant p53 stimulates cell invasion through an interaction with Rad21 in human ovarian cancer cells

16 Aug 2017

Abstract excerpt

Abstract Missense mutations of TP53 are extremely common, and mutant p53 accumulation and gain-of-function play crucial roles in human ovarian cancer. Here, we investigated the role of mutant p53 in cell migration and invasion as well as its underlying molecular mechanisms in human ovarian cancer cells. Overexpression of mutant p53 significantly increased migration and invasion in p53-null SKOV3 cells. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to interferon and immune responses
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28831167
DOI: 10.1038/s41598-017-08880-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant p53 stimulates cell invasion through an interaction with Rad21 in human ovarian cancer cellsPMID 28831167Read ↗

Dominant-negative p53 mutant R248Q increases the motile and invasive activities of oral squamous cell carcinoma cellsSemantic proximity Read ↗

Deficient or R273H and R248W Mutations of p53 Promote Chemoresistance to 5-FU via TCF21/CD44 Axis-Mediated Enhanced Stemness in Colorectal CarcinomaSemantic proximity Read ↗

Gain-of-Function Mutant TP53 R248Q Overexpressed in Epithelial Ovarian Carcinoma Alters AKT-Dependent Regulation of Intercellular Trafficking in Responses to EGFR/MDM2 InhibitorSemantic proximity Read ↗

Mutant TP53 interacts with BCAR1 to contribute to cancer cell invasion.Semantic proximity Read ↗

Pla2g16 phospholipase mediates gain-of-function activities of mutant p53.Semantic proximity Read ↗

Mutant p53 on the Path to Metastasis.Semantic proximity Read ↗

Mutant p53 promotes cell spreading and migration via ARHGAP44.Semantic proximity Read ↗

Reactivating p53 functions by suppressing its novel inhibitor iASPP: a potential therapeutic opportunity in p53 wild-type tumorsSemantic proximity Read ↗

Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal CancerSemantic proximity Read ↗

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of SlugSemantic proximity Read ↗

p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression.Semantic proximity Read ↗

p53-independent p21 induction by MELK inhibitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.