Article
Cdkn2a suppresses metastasis in squamous cell carcinomas induced by the gain-of-function mutant p53(R172H).
The Journal of pathology - 1 Oct 2016
Li Zhongyou, Gonzalez Cassandra L, Wang Bingbing, Zhang Yuanyuan, Mejia Olga, Katsonis Panagiotis, Lichtarge Olivier, Myers Jeffrey N, El-Naggar Adel K, Caulin Carlos
Abstract excerpt
p53 (TP53) is the most frequently mutated gene in squamous cell carcinomas (SCCs) of the skin and head and neck. Certain p53 mutations are oncogenic and promote invasion and metastasis in SCCs. However, it is unclear how the oncogenic function of mutant p53 is modulated by other molecular alterations that co-exist in SCCs. Here, we show that deletion of the p53 gene and activation of an endogenous p53(R172H)...
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