Article
Gain-of-function mutations in the tumor suppressor gene p53.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2000
van Oijen M G, Slootweg P J
Abstract excerpt
The tumor suppressor protein p53 is a multifunctional transcription factor involved in the control of cell cycle progression, DNA integrity, and cell survival. p53 is mutated in half of all tumors and has a wide spectrum of mutation types. p53 mutants show different degrees of dominance over coexpressed wild-type p53, and loss of the wild-type p53 allele has been observed frequently. Several p53 mutants can exert...
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