Article
Oncogenic mutation of the p53 gene derived from head and neck cancer prevents cells from undergoing apoptosis after DNA damage.
International journal of oncology - 1 May 2007
Kawamata Hitoshi, Omotehara Fumie, Nakashiro Koh-Ichi, Uchida Daisuke, Shinagawa Yasuhiro, Tachibana Masatsugu, Imai Yutaka, Fujimori Takahiro
Abstract excerpt
A p53 functional analysis system, which can identify the types of abnormality of p53, such as loss of function, dominant negative function, or gain of oncogenic function, is now required. In this study, we examined the functional diversity of several mutations of p53 derived from human head and neck cancer cells. The entire open reading frame of p53 cDNA was subcloned into a mammalian expression vector, pEGFP-C3,...
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