Mutant p53 gain of oncogenic function: in vivo evidence, mechanism of action and its clinical implications.

Abstract excerpt

p53 is an indispensible tumor suppressor and exerts this function by transactivating numerous downstream target genes that play vital roles in controlling cell proliferation, apoptosis, senescence, and DNA repair. Mutations in the p53 gene, which are frequently seen in human tumors, impair its tumor suppressor function. Several of these tumor-derived p53 mutants can confer further aggressive oncogenic properties...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genes, p53
• Share to Li-Fraumeni Syndrome
• Share to Mice