Article
Mutant p53 proteins: between loss and gain of function.
Head & neck - 1 May 2007
Strano Sabrina, Dell'Orso Stefania, Mongiovi Adriana Maria, Monti Olimpia, Lapi Eleonora, Di Agostino Silvia, Fontemaggi Giulia, Blandino Giovanni
Abstract excerpt
Cancer might result from both the aberrant activation of genes, whose physiological tuning is essential for the life of a normal cell, and the inactivation of tumor suppressor genes, whose main job is to preserve the integrity of cell genome. Among the latter, p53 is considered a key tumor suppressor gene that is inactivated mainly by missense mutations in half of human cancers. It is becoming increasingly clear...
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