Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy

8 Feb 2019

Abstract excerpt

Genomic changes observed across treatment may result from either clonal evolution or geographically disparate sampling of heterogeneous tumors. Here we use computational modeling based on analysis of fifteen primary breast tumors and find that apparent clonal change between two tumor samples can frequently be explained by pre-treatment heterogeneity, such that at least two regions are necessary to detect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Gene expression and cancer classification
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30737380
DOI: 10.1038/s41467-019-08593-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapyPMID 30737380Read ↗

Intra-tumor heterogeneity defines treatment-resistant HER2+ breast tumorsSemantic proximity Read ↗

Intratumor heterogeneity defines treatment‐resistant HER 2+ breast tumorsSemantic proximity Read ↗

Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer.Semantic proximity Read ↗

The clonal and mutational evolution spectrum of primary triple-negative breast cancers.Semantic proximity Read ↗

Subclonal diversification of primary breast cancer revealed by multiregion sequencing.Semantic proximity Read ↗

Combating subclonal evolution of resistant cancer phenotypes.Semantic proximity Read ↗

Intratumor Heterogeneity: Novel Approaches for Resolving Genomic Architecture and Clonal EvolutionSemantic proximity Read ↗

Adaptation and selection shape clonal evolution of tumors during residual disease and recurrenceSemantic proximity Read ↗

Clonal selection supported by single cell Dna sequencing reveals hormonal adaptation and resistance in locally advanced breast cancer During Neoadjuvant Aromatase InhibitionSemantic proximity Read ↗

The clonal architecture and tumour microenvironment of breast cancers are shaped by neoadjuvant chemotherapySemantic proximity Read ↗

Modeling clonal structure over narrow time frames via circulating tumor DNA in metastatic breast cancer.Semantic proximity Read ↗

Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.