Article

Intra-tumor heterogeneity defines treatment-resistant HER2+ breast tumors

2018-04-18

Abstract excerpt

Targeted therapy for patients with HER2 positive (HER2+) breast cancer has improved the overall survival, but many patients still suffer relapse and death of the disease. Intra-tumor heterogeneity of both estrogen receptor (ER) and HER2 expression has been proposed to play a key role in treatment failure, but little work has been done to comprehensively study this heterogeneity at the single-cell level. In this st...

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Literature Corpus work: 4ef90697-5d25-526e-ab64-7111cf4a2c78
DOI: 10.1101/297549

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