Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity.

doi:10.1016/j.celrep.2013.12.041

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Article

Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity.

Cell reports - 13 Feb 2014

Almendro Vanessa, Cheng Yu-Kang, Randles Amanda, Itzkovitz Shalev, Marusyk Andriy, Ametller Elisabet, Gonzalez-Farre Xavier, Muñoz Montse, Russnes Hege G, Helland Aslaug, Rye Inga H, Borresen-Dale Anne-Lise, Maruyama Reo, van Oudenaarden Alexander, Dowsett Mitchell, Jones Robin L, Reis-Filho Jorge, Gascon Pere, Gönen Mithat, Michor Franziska, Polyak Kornelia

Abstract excerpt

Cancer therapy exerts a strong selection pressure that shapes tumor evolution, yet our knowledge of how tumors change during treatment is limited. Here, we report the analysis of cellular heterogeneity for genetic and phenotypic features and their spatial distribution in breast tumors pre- and post-neoadjuvant chemotherapy. We found that intratumor genetic diversity was tumor-subtype specific, and it did not...

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PMID: 24462293
DOI: 10.1016/j.celrep.2013.12.041
PMCID: PMC3928845

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