Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios.

Journal of lipid research - 1 Aug 2010

Bokor Szilvia, Dumont Julie, Spinneker Andre, Gonzalez-Gross Marcela, Nova Esther, Widhalm Kurt, Moschonis George, Stehle Peter, Amouyel Philippe, De Henauw Stefaan, Molnàr Dènes, Moreno Luis A, Meirhaeghe Aline, Dallongeville Jean

Abstract excerpt

Genetic variability in the FADS1-FADS2 gene cluster [encoding delta-5 (D5D) and delta-6 (D6D) desaturases] has been associated with plasma long-chain PUFA (LCPUFA) and lipid levels in adults. To better understand these relationships, we further characterized the association between FADS1-FADS2 genetic variability and D5D and D6D activities in adolescents. Thirteen single nucleotide polymorphisms (SNPs) were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Body Mass Index

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Delta-5 Fatty Acid Desaturase

Share to Fatty Acid Desaturases

Share to Fatty Acids

Share to Fatty Acids, Unsaturated

Share to Haplotypes

Share to Multigene Family

Source

Open in PubMed Open full text

Identifiers

PMID: 20427696
DOI: 10.1194/jlr.M006205
PMCID: PMC2903808

Genes

FADS1
FADS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios.PMID 20427696Read ↗

Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplementSemantic proximity Read ↗

A common variant in ARHGEF10 alters delta-6 desaturase activity and influence susceptibility to hypertriglyceridemia.Semantic proximity Read ↗

FADS2 polymorphisms are associated with plasma arachidonic acid and estimated desaturase-5 activity in a cross-sectional study.Semantic proximity Read ↗

FADS1 gene polymorphism(s) and fatty acid composition of serum lipids in adolescents.Semantic proximity Read ↗

Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.Semantic proximity Read ↗

FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes.Semantic proximity Read ↗

Genetically determined variation in polyunsaturated fatty acid metabolism may result in different dietary requirements.Semantic proximity Read ↗

FADS genetic and metabolomic analyses identify the ∆5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids.Semantic proximity Read ↗

Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism.Semantic proximity Read ↗

Association between FADS1 rs174547 and levels of long-chain PUFA: a meta-analysis.Semantic proximity Read ↗

Variation in the FADS1/2 gene cluster alters plasma n-6 PUFA and is weakly associated with hsCRP levels in healthy young adults.Semantic proximity Read ↗

Identification of a functional FADS1 3'UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.