Article
A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology.
Blood - 28 Feb 2019
de Vries Paul S, Sabater-Lleal Maria, Huffman Jennifer E, Marten Jonathan, Song Ci, Pankratz Nathan, Bartz Traci M, de Haan Hugoline G, Delgado Graciela E, Eicher John D, Martinez-Perez Angel, Ward-Caviness Cavin K, Brody Jennifer A, Chen Ming-Huei, de Maat Moniek P M, Frånberg Mattias, Gill Dipender, Kleber Marcus E, Rivadeneira Fernando, Soria José Manuel, Tang Weihong, Tofler Geoffrey H, Uitterlinden André G, van Hylckama Vlieg Astrid, Seshadri Sudha, Boerwinkle Eric, Davies Neil M, Giese Anne-Katrin, Ikram M Kamran, Kittner Steven J, McKnight Barbara, Psaty Bruce M, Reiner Alex P, Sargurupremraj Muralidharan, Taylor Kent D, Fornage Myriam, Hamsten Anders, März Winfried, Rosendaal Frits R, Souto Juan Carlos, Dehghan Abbas, Johnson Andrew D, Morrison Alanna C, O'Donnell Christopher J, Smith Nicholas L
Abstract excerpt
Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of 9 genome-wide association studies of plasma FVII levels (7 FVII activity and 2 FVII antigen) among 27 495 participants of European and African ancestry. Each study performed ancestry-specific association analyses. Inverse...
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