Article
Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium.
Circulation - 30 Mar 2010
Smith Nicholas L, Chen Ming-Huei, Dehghan Abbas, Strachan David P, Basu Saonli, Soranzo Nicole, Hayward Caroline, Rudan Igor, Sabater-Lleal Maria, Bis Joshua C, de Maat Moniek P M, Rumley Ann, Kong Xiaoxiao, Yang Qiong, Williams Frances M K, Vitart Veronique, Campbell Harry, Mälarstig Anders, Wiggins Kerri L, Van Duijn Cornelia M, McArdle Wendy L, Pankow James S, Johnson Andrew D, Silveira Angela, McKnight Barbara, Uitterlinden Andre G, Aleksic Nena, Meigs James B, Peters Annette, Koenig Wolfgang, Cushman Mary, Kathiresan Sekar, Rotter Jerome I, Bovill Edwin G, Hofman Albert, Boerwinkle Eric, Tofler Geoffrey H, Peden John F, Psaty Bruce M, Leebeek Frank, Folsom Aaron R, Larson Martin G, Spector Timothy D, Wright Alan F, Wilson James F, Hamsten Anders, Lumley Thomas, Witteman Jacqueline C M, Tang Weihong, O'Donnell Christopher J
Abstract excerpt
BACKGROUND: Plasma levels of coagulation factors VII (FVII), VIII (FVIII), and von Willebrand factor (vWF) influence risk of hemorrhage and thrombosis. We conducted genome-wide association studies to identify new loci associated with plasma levels. METHODS AND RESULTS: The setting of the study included 5 community-based studies for discovery comprising 23 608 European-ancestry participants: Atherosclerosis Risk...
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