Article
A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium.
Human molecular genetics - 1 Sept 2011
Taylor Kira C, Lange Leslie A, Zabaneh Delilah, Lange Ethan, Keating Brendan J, Tang Weihong, Smith Nicholas L, Delaney Joseph A, Kumari Meena, Hingorani Aroon, North Kari E, Kivimaki Mika, Tracy Russell P, O'Donnell Christopher J, Folsom Aaron R, Green David, Humphries Steve E, Reiner Alexander P
Abstract excerpt
Polymorphisms in several distinct genomic regions, including the F7 gene, were recently associated with factor VII (FVII) levels in European Americans (EAs). The genetic determinants of FVII in African Americans (AAs) are unknown. We used a 50,000 single nucleotide polymorphism (SNP) gene-centric array having dense coverage of over 2,000 candidate genes for cardiovascular disease (CVD) pathways in a...
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