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Article

Establishment of TP53-knockout canine cells using optimized CRIPSR/Cas9 vector system for canine cancer research

3 Jan 2019

Abstract excerpt

BACKGROUND: Genetic engineering technology such as clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system provides a powerful tool for developing disease models and determining gene functions. Recent interests in canine cancer models have highlighted the necessity of developing genetic engineering tools for dogs. In this study, we attempted to generate optimized CRISPR/Cas9 system to...

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PMID: 30606176
DOI: 10.1186/s12896-018-0491-5

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