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Article

DNA damage response proteins in canine cancer as potential research targets in comparative oncology.

Veterinary and comparative oncology - 1 Jun 2022

Hernández-Suárez Beatriz, Gillespie David A, Pawlak Aleksandra

Abstract excerpt

The DNA damage response (DDR) is a complex signal transduction network that is activated when endogenous or exogenous genotoxins damage or interfere with the replication of genomic DNA. Under such conditions, the DDR promotes DNA repair and ensures accurate replication and division of the genome. High levels of genomic instability are frequently observed in cancers and can stem from germline loss-of-function...

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Identifiers

PMID: 34923737
DOI: 10.1111/vco.12795
PMCID: PMC9304296

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