Article

Generation of a dystrophin mutant dog by nuclear transfer using CRISPR/Cas9-mediated somatic cells

2021-04-14

Abstract excerpt

<title>Abstract</title> <p>Dystrophinopathy is caused by mutations in the dystrophin gene, which lead to progressive muscle degeneration, necrosis, and finally death. Recently, golden retrievers have been suggested as a useful animal model for studying human dystrophinopathy, but the model has limitations due to difficulty in maintaining the genetic background using conventional breeding. In this study, we succes...

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Literature Corpus work: 6bd4aa8f-8628-5cde-8a39-0133181e91a4
DOI: 10.21203/rs.3.rs-407457/v1

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