Article

Generation of Genome-Edited Dogs by Somatic Cell Nuclear Transfer

2021-10-21

Abstract excerpt

<h4>Background: </h4> Canine cloning technology based on somatic cell nuclear transfer (SCNT) combined with genome editing tools, such as CRISPR/Cas9, can be used to correct pathogenic mutations in purebred dogs or to generate animal models of disease. <h4>Results: </h4>: In this study, we constructed a CRISPR/Cas9 vector construct targeting the canine DJ-1 gene. Genome-edited canine fibroblasts were established b...

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Literature Corpus work: e9f45d60-74d5-55bc-9b10-8955cef73fe6
DOI: 10.21203/rs.3.rs-962421/v1

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