Article
Systematic analyses of regulatory variants in DNase I hypersensitive sites identified two novel lung cancer susceptibility loci.
Carcinogenesis - 14 May 2019
Dai Juncheng, Li Zhihua, Amos Christopher I, Hung Rayjean J, Tardon Adonina, Andrew Angeline S, Chen Chu, Christiani David C, Albanes Demetrios, van der Heijden Erik H F M, Duell Eric J, Rennert Gad, Mckay James D, Yuan Jian-Min, Field John K, Manjer Jonas, Grankvist Kjell, Le Marchand Loic, Teare M Dawn, Schabath Matthew B, Aldrich Melinda C, Tsao Ming-Sound, Lazarus Philip, Lam Stephen, Bojesen Stig E, Arnold Susanne, Wu Xifeng, Haugen Aage, Janout Vladimir, Johansson Mikael, Brhane Yonathan, Fernandez-Somoano Ana, Kiemeney Lambertus A, Davies Michael P A, Zienolddiny Shanbeh, Hu Zhibin, Shen Hongbing
Abstract excerpt
DNase I hypersensitive sites (DHS) are abundant in regulatory elements, such as promoter, enhancer and transcription factor binding sites. Many studies have revealed that disease-associated variants were concentrated in DHS-related regions. However, limited studies are available on the roles of DHS-related variants in lung cancer. In this study, we performed a large-scale case-control study with 20 871 lung...
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