Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma.

doi:10.1007/s11684-020-0779-4

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Article

Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma.

Frontiers of medicine - 1 Apr 2021

Qin Na, Li Yuancheng, Wang Cheng, Zhu Meng, Dai Juncheng, Hong Tongtong, Albanes Demetrius, Lam Stephen, Tardon Adonina, Chen Chu, Goodman Gary, Bojesen Stig E, Landi Maria Teresa, Johansson Mattias, Risch Angela, Wichmann H-Erich, Bickeboller Heike, Rennert Gadi, Arnold Susanne, Brennan Paul, Field John K, Shete Sanjay, Le Marchand Loic, Melander Olle, Brunnstrom Hans, Liu Geoffrey, Hung Rayjean J, Andrew Angeline, Kiemeney Lambertus A, Zienolddiny Shan, Grankvist Kjell, Johansson Mikael, Caporaso Neil, Woll Penella, Lazarus Philip, Schabath Matthew B, Aldrich Melinda C, Stevens Victoria L, Jin Guangfu, Christiani David C, Hu Zhibin, Amos Christopher I, Ma Hongxia, Shen Hongbing

Abstract excerpt

Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer (NSCLC) risk, biological mechanisms of these variants remain largely unknown. By integrating a large-scale genotype data of 15 581 lung adenocarcinoma (AD) cases, 8350 squamous cell carcinoma (SqCC) cases, and 27 355 controls, as well as multiple transcriptome and epigenomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32889700
DOI: 10.1007/s11684-020-0779-4
PMCID: PMC8374896

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