Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The inherited variations of a p53-responsive enhancer in 13q12.12 confer lung cancer risk by attenuating TNFRSF19 expression

24 May 2019

Abstract excerpt

BACKGROUND: Inherited factors contribute to lung cancer risk, but the mechanism is not well understood. Defining the biological consequence of GWAS hits in cancers is a promising strategy to elucidate the inherited mechanisms of cancers. The tag-SNP rs753955 (A>G) in 13q12.12 is highly associated with lung cancer risk in the Chinese population. Here, we systematically investigate the biological significance and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomics and Chromatin Dynamics

Source

Identifiers

PMID: 31126313
DOI: 10.1186/s13059-019-1696-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The inherited variations of a p53-responsive enhancer in 13q12.12 confer lung cancer risk by attenuating TNFRSF19 expressionPMID 31126313Read ↗

The enhancer rare germline variation rs548071605 contributes to lung cancer development.Semantic proximity Read ↗

An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression.Semantic proximity Read ↗

Systematic analyses of regulatory variants in DNase I hypersensitive sites identified two novel lung cancer susceptibility loci.Semantic proximity Read ↗

Rare Variants in Known Susceptibility Loci and Their Contribution to Risk of Lung Cancer.Semantic proximity Read ↗

Germline determinants of risk and molecular subtype in young-onset lung cancerSemantic proximity Read ↗

Genome-wide association study of familial lung cancer.Semantic proximity Read ↗

Leveraging Tissue-Specific Enhancer-Target Gene Regulatory Networks Identifies Enhancer Somatic Mutations That Functionally Impact Lung Cancer.Semantic proximity Read ↗

A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese.Semantic proximity Read ↗

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.Semantic proximity Read ↗

Comprehensive functional interrogation of susceptibility loci in GWASs identified KIAA0391 as a novel oncogenic driver via regulating pyroptosis in NSCLC.Semantic proximity Read ↗

Genetic susceptibility to lung squamous cell carcinoma: new insights on 9q33.2 variants and tobacco smoking.Semantic proximity Read ↗

Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.