Article
Integrating expression-related SNPs into genome-wide gene- and pathway-based analyses identified novel lung cancer susceptibility genes.
International journal of cancer - 15 Apr 2018
Wang Yuzhuo, Wu Weibing, Zhu Meng, Wang Cheng, Shen Wei, Cheng Yang, Geng Liguo, Li Zhihua, Zhang Jiahui, Dai Juncheng, Ma Hongxia, Chen Liang, Hu Zhibin, Jin Guangfu, Shen Hongbing
Abstract excerpt
Traditional pathway analysis map single nucleotide polymorphisms (SNPs) to genes according to physical position, which lacks sufficient biological bases. Here, we incorporated genetics of gene expression into gene- and pathway-based analysis to identify genes and pathways associated with lung cancer risk. We identified expression-related SNPs (eSNPs) in lung tissues and integrated these eSNPs into three lung...
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