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The role of Eomes in human CD4 T cell differentiation: A question of context

8 Dec 2018

Abstract excerpt

Abstract Eomesodermin (Eomes) is a transcription factor (TF) of the T‐box family closely related to T‐bet known for its role in CD8 T cell and natural killer cell differentiation. However, the role of Eomes in CD4 T‐cell differentiation is less well appreciated. In this issue of the European Journal of Immunology [Eur. J. Immunol. 2019. 49: 79–95] Mazzoni et al. and [Eur. J. Immunol. 2019. 49: 96–111] Gruarin et...

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Identifiers

PMID: 30536524
DOI: 10.1002/eji.201848000

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The role of Eomes in human CD4 T cell differentiation: A question of contextPMID 30536524Read ↗

Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation.Semantic proximity Read ↗

Eomesodermin Controls Interleukin-5 Production in Memory T Helper 2 Cells through Inhibition of Activity of the Transcription Factor GATA3Semantic proximity Read ↗

EOMES and IL-10 regulate anti-tumor activity of PD-1 <sup>+</sup> CD4 <sup>+</sup> T-cells in B-cell Non-Hodgkin lymphomaSemantic proximity Read ↗

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Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin.Semantic proximity Read ↗

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Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of EomesSemantic proximity Read ↗

Insufficient interleukin-12 signalling favours differentiation of human CD4(+) and CD8(+) T cells into GATA-3(+) and GATA-3(+) T-bet(+) subsets in humanized mice.Semantic proximity Read ↗

T-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17.Semantic proximity Read ↗

T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells.Semantic proximity Read ↗

Differential localization of T-bet and Eomes in CD8 T cell memory populations.Semantic proximity Read ↗

CRTAM determines the CD4+ cytotoxic T lymphocyte lineage.Semantic proximity Read ↗

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