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Article

T-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2008

Yang Yu, Xu Jiangnan, Niu Yanyan, Bromberg Jonathan S, Ding Yaozhong

Abstract excerpt

Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. By adding Stat6 deficiency to T-bet deficiency, and thus negating effects from elevated levels of IL-4/Stat6/GATA3 Th2 signals in T-bet-deficient cells, we investigated the signals important for Th1 and Th17 cell differentiation and their role in colitis development. The data reveal that Eomesodermin compensates T-bet...

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Source

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Identifiers

PMID: 19050290
DOI: 10.4049/jimmunol.181.12.8700
PMCID: PMC2834216

Genes

GATA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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