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Article

T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells.

Frontiers in immunology - 1 Jan 2021

Kiekens Laura, Van Loocke Wouter, Taveirne Sylvie, Wahlen Sigrid, Persyn Eva, Van Ammel Els, De Vos Zenzi, Matthys Patrick, Van Nieuwerburgh Filip, Taghon Tom, Van Vlierberghe Pieter, Vandekerckhove Bart, Leclercq Georges

Abstract excerpt

T-bet and Eomes are transcription factors that are known to be important in maturation and function of murine natural killer (NK) cells. Reduced T-BET and EOMES expression results in dysfunctional NK cells and failure to control tumor growth. In contrast to mice, the current knowledge on the role of T-BET and EOMES in human NK cells is rudimentary. Here, we ectopically expressed either T-BET or EOMES in human...

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Identifiers

PMID: 34630413
DOI: 10.3389/fimmu.2021.732511
PMCID: PMC8497824

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