Article
Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin.
PloS one - 13 May 2010
Narayanan Sriram, Silva Rodolfo, Peruzzi Giovanna, Alvarez Yelina, Simhadri Venkateswara R, Debell Karen, Coligan John E, Borrego Francisco
Abstract excerpt
Human naïve CD4 T cells express low levels of the immunomodulatory receptor CD300a, whereas effector/memory CD4 cells can be either CD300a(+) or CD300a(-). This suggested that CD300a expression could define a specific subset within the effector/memory CD4 T cell subpopulations. In fact, ex vivo analysis of the IFN-gamma producing CD4 T cells showed that they are enriched in the CD300a(+) subset. Moreover,...
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