Article
CRTAM determines the CD4+ cytotoxic T lymphocyte lineage.
The Journal of experimental medicine - 11 Jan 2016
Takeuchi Arata, Badr Mohamed El Sherif Gadelhaq, Miyauchi Kosuke, Ishihara Chitose, Onishi Reiko, Guo Zijin, Sasaki Yoshiteru, Ike Hiroshi, Takumi Akiko, Tsuji Noriko M, Murakami Yoshinori, Katakai Tomoya, Kubo Masato, Saito Takashi
Abstract excerpt
Naive T cells differentiate into various effector T cells, including CD4(+) helper T cell subsets and CD8(+) cytotoxic T cells (CTL). Although cytotoxic CD4(+) T cells (CD4 +: CTL) also develop from naive T cells, the mechanism of development is elusive. We found that a small fraction of CD4(+) T cells that express class I-restricted T cell-associated molecule (CRTAM) upon activation possesses the characteristics...
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