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Article

NSD2 is a conserved driver of metastatic prostate cancer progression

29 Nov 2018

Abstract excerpt

Deciphering cell-intrinsic mechanisms of metastasis progression in vivo is essential to identify novel therapeutic approaches. Here we elucidate cell-intrinsic drivers of metastatic prostate cancer progression through analyses of genetically engineered mouse models (GEMM) and correlative studies of human prostate cancer. Expression profiling of lineage-marked cells from mouse primary tumors and metastases defines...

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PMID: 30518758
DOI: 10.1038/s41467-018-07511-4

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