Article

Clinically relevant humanized mouse models of metastatic prostate cancer to evaluate cancer therapies

2023-10-18

Abstract excerpt

There is tremendous need for improved prostate cancer (PCa) models. The mouse prostate does not spontaneously form tumors and is anatomically and developmentally different from the human prostate. Engineered mouse models lack the heterogeneity of human cancer and rarely establish metastatic growth. Human xenografts represent an alternative but rely on an immunocompromised host. Accordingly, we generated PCa murine...

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Identifiers and source

Literature Corpus work: 625476db-d229-516b-b3df-4d957138a184
DOI: 10.1101/2023.10.13.562280

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