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Article

<i>ETV4</i> promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer

5 Aug 2013

Abstract excerpt

Combinatorial activation of PI3-kinase and RAS signaling occurs frequently in advanced prostate cancer and is associated with adverse patient outcome. We now report that the oncogenic Ets variant 4 (Etv4) promotes prostate cancer metastasis in response to coactivation of PI3-kinase and Ras signaling pathways in a genetically engineered mouse model of highly penetrant, metastatic prostate cancer. Using an...

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PMID: 23918374
DOI: 10.1073/pnas.1303558110

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