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Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer

7 Jun 2021

Abstract excerpt

Despite advances in the development of highly effective androgen receptor (AR)-directed therapies for the treatment of men with advanced prostate cancer, acquired resistance to such therapies frequently ensues. A significant subset of patients with resistant disease develop AR-negative tumors that lose their luminal identity and display neuroendocrine features (neuroendocrine prostate cancer (NEPC)). The cellular...

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PMID: 34099734
DOI: 10.1038/s41467-021-23780-y

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