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Article

Epigenetic dysregulation of Oxtr in Tet1-deficient mice has implications for neuropsychiatric disorders.

JCI insight - 6 Dec 2018

Towers Aaron J, Tremblay Martine W, Chung Leeyup, Li Xin-Lei, Bey Alexandra L, Zhang Wenhao, Cao Xinyu, Wang Xiaoming, Wang Ping, Duffney Lara J, Siecinski Stephen K, Xu Sonia, Kim Yuna, Kong Xiangyin, Gregory Simon, Xie Wei, Jiang Yong-Hui

Abstract excerpt

OXTR modulates a variety of behaviors in mammals, including social memory and recognition. Genetic and epigenetic dysregulation of OXTR has been suggested to be implicated in neuropsychiatric disorders, including autism spectrum disorder (ASD). While the involvement of DNA methylation is suggested, the mechanism underlying epigenetic regulation of OXTR is largely unknown. This has hampered the experimental design...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Oxytocin

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Source

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Identifiers

PMID: 30518695
DOI: 10.1172/jci.insight.120592
PMCID: PMC6328031

Genes

OXTR
TET1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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