Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder.

Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 2014

Parker Karen J, Garner Joseph P, Libove Robin A, Hyde Shellie A, Hornbeak Kirsten B, Carson Dean S, Liao Chun-Ping, Phillips Jennifer M, Hallmayer Joachim F, Hardan Antonio Y

Abstract excerpt

The neuropeptide oxytocin (OXT) and its receptor (OXTR) regulate social functioning in animals and humans. Initial clinical research suggests that dysregulated plasma OXT concentrations and/or OXTR SNPs may be biomarkers of social impairments in autism spectrum disorder (ASD). We do not know, however, whether OXT dysregulation is unique to ASD or whether OXT biology influences social functioning more generally,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child Development Disorders, Pervasive

Share to Child, Preschool

Share to Oxytocin

Share to Polymorphism, Genetic

Share to Receptors, Oxytocin

Share to Social Behavior

Source

Open in PubMed Open full text

Identifiers

PMID: 25092315
DOI: 10.1073/pnas.1402236111
PMCID: PMC4143031

Genes

OXT
OXTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder.PMID 25092315Read ↗

The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: a meta-analysis.Semantic proximity Read ↗

Oxytocin Receptor Polymorphisms are Differentially Associated with Social Abilities across Neurodevelopmental Disorders.Semantic proximity Read ↗

Evidence for Association Between OXTR Gene and ASD Clinical Phenotypes.Semantic proximity Read ↗

Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition.Semantic proximity Read ↗

Genetic variation in the oxytocin receptor gene is associated with a social phenotype in autism spectrum disorders.Semantic proximity Read ↗

Oxytocin Pathway Genes: Evolutionary Ancient System Impacting on Human Affiliation, Sociality, and Psychopathology.Semantic proximity Read ↗

Examining autism spectrum disorders by biomarkers: example from the oxytocin and serotonin systems.Semantic proximity Read ↗

Meta-analysis and association of two common polymorphisms of the human oxytocin receptor gene in autism spectrum disorder.Semantic proximity Read ↗

Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population.Semantic proximity Read ↗

Sensitive parenting is associated with plasma oxytocin and polymorphisms in the OXTR and CD38 genes.Semantic proximity Read ↗

Oxytocin receptor gene variations predict neural and behavioral response to oxytocin in autism.Semantic proximity Read ↗

Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.