Deciphering autism heterogeneity: a molecular stratification approach in four mouse models

Abstract excerpt

<title>Abstract</title> <p>Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by impairments in social interaction, communication, as well as restrained or stereotyped behaviors. The inherent heterogeneity within the autism spectrum poses challenges for developing effective pharmacological treatments targeting core features. Successful clinical trials require the identification...

Topics

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• Autistic Disorder
• Fragile X Mental Retardation Protein
• Fragile X Syndrome
• Genetics, Behavioral
• Methyl-CpG-Binding Protein 2
• Mice, Mutant Strains
• Rett Syndrome
• Synapses

Identifiers and source

Literature Corpus work

1df305fb-6372-537c-8d1c-eb14182b4094

DOI

10.21203/rs.3.rs-4235527/v1