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Article

Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 2005

Takayanagi Yuki, Yoshida Masahide, Bielsky Isadora F, Ross Heather E, Kawamata Masaki, Onaka Tatsushi, Yanagisawa Teruyuki, Kimura Tadashi, Matzuk Martin M, Young Larry J, Nishimori Katsuhiko

Abstract excerpt

The oxytocin receptor (OXTR) and its ligand, oxytocin (OXT), regulate reproductive physiology (i.e., parturition and lactation) and sociosexual behaviors. To define the essential functions of OXTR, we generated mice with a null mutation in the Oxtr gene (Oxtr(-/-)) and compared them with OXT-deficient (Oxt(-/-)) mice. Oxtr(-/-) mice were viable and had no obvious deficits in fertility or reproductive behavior....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16249339
DOI: 10.1073/pnas.0505312102
PMCID: PMC1276060

Genes

OXTR
OXT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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