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Article

TET1 displays catalytic and non-catalytic functions in the adult mouse cortex.

Epigenetics - 1 Dec 2024

Foong Yee Hoon, Caldwell Blake, Thorvaldsen Joanne L, Krapp Christopher, Mesaros Clementina A, Zhou Wanding, Kohli Rahul M, Bartolomei Marisa S

Abstract excerpt

TET1/2/3 dioxygenases iteratively demethylate 5-methylcytosine, beginning with the formation of 5-hydroxymethylcytosine (5hmC). The post-mitotic brain maintains higher levels of 5hmC than most peripheral tissues, and TET1 ablation studies have underscored the critical role of TET1 in brain physiology. However, deletion of Tet1 precludes the disentangling of the catalytic and non-catalytic functions of TET1. Here,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38970823
DOI: 10.1080/15592294.2024.2374979
PMCID: PMC11229741

Genes

TET1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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