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A Primate-Specific Isoform of PLEKHG6 Regulates Neurogenesis and Neuronal Migration

1 Dec 2018

Abstract excerpt

The mammalian neocortex has undergone remarkable changes through evolution. A consequence of such rapid evolutionary events could be a trade-off that has rendered the brain susceptible to certain neurodevelopmental and neuropsychiatric conditions. We analyzed the exomes of 65 patients with the structural brain malformation periventricular nodular heterotopia (PH). De novo coding variants were observed in excess...

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PMID: 30517861
DOI: 10.1016/j.celrep.2018.11.029

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